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*KLOTHO gene was discovered in 1997, in mice, to extend the lifespan when overexpressed, while it accelerates aging when its expression is disrupted.
The name of this longevity gene comes from the Greek goddess Klotho. In Greek mythology, it was Klotho who controlled the lives and destinies of everyone.
The Klotho gene codes for a transmembrane protein, the extracellular domain of which is shed and secreted.
The secreted Klotho protein inhibits the phosphorylation of the IGF1 receptor which leads to the repression of the insulin / IGF-1 pathway. Therefore, Klotho activity results in an activation of **FOXO. Activation of FOXO will induce anti-aging activity by stimulating detoxification and DNA-repair genes.
YOUTH EXPERT™ Ultimate Corrective Cream is a powerful and innovative anti-aging cream designed for intensive re-densification and re-contouring of face, neck and decollete – real results™. Cream is suitable for daily care for skin of all types with lack of cohesion and visible sagging. Not recommended before aged 40.
Main components – FLEX-UP Sculpting™ composition:
Stimulation of natural growth factors of skin: Placental Proteins
Repair of Extra-Cellular Matrix (ECM): Crocus Chrysanthus Extract
Dermal strength improvement: Xymeninic Acid (restructuring of tissue architecture)
Contouring and lifting: Lipodipeptide Tyrosyl-Arginyl + Crystal Tears™
Nutrition: Apitoxin/Bee Venom (rich in proteins, peptides, phospholipids, amino acids, minerals)
Microcirculation: Caffeine + Troxerutin (derivative of plant-derived Rutin)
Hydration: Polyglyceryl-3 PCA + Hyaluronic Acid 50kDa
Lipid-restore: Lauryl Olivate (Hydrolipidic Dermollient)
UV/Sun protection: UV filters (Sunglasses for the Skin™)
Anti-oxidant: Vitamin E
1. Technology FLEX-UP Sculpting™ is the most powerful anti-gravity system offered by DERMEDICS®. It is an outstanding combination of the most powerful age reversing components (which are partly known from ECM and GEN’X collections) blended with the newest cosmetic ingredients available nowadays on world’s beauty market. This intensive formula is created for re-densifying and re-contouring the skin, thus to reverse skin sagging caused by gravity through:
Stimulating keratinocytes to secrete growth factors that could enhance the synthesis of collagen and elastin in the dermis (this effect on fibroblasts was comparable to the one of the transforming growth factor (TGF-β), a natural growth factor involved in ECM synthesis)
2. Sunglasses for the Skin™ - innovative UV filters encapsulated into micro-pearls to provide protection for the skin and to prevent direct contact with the skin ensuring optimum comfort which allows for both day and night application. UV filters are inactive during night.
Cream contains UV filters and that is why it is recommended to be used during a day (itself or prior makeup). However, it can be used also during a night (if desired), because during a night UV filters are inactive and they have no impact on skin.
Main target: face, neck, décolletage.
Optional: top parts of hands and other (if desired).
Ultimate Corrective Cream
For external use only. Keep out of the reach of children.
Contraindications: hypersensitivity to any component of the formulation (especially on bee venom).
Water/Aqua, Butylene Glycol, Ethylhexyl Methoxycinnamate, Glyceryl Stearate, Polyquaternium-37, Polyimide-1, PEG-100 Stearate, Glycerin, Hydrogenated Palm Kernel Glycerides, Hydrogenated Palm Glycerides, Lauryl Olivate, Myristyl Myristate, Polyglyceryl-3 PCA, Troxerutin, Placental Protein, Acacia Senegal Gum, Xymenynic Acid, Caffeine, Hydrolyzed Hyaluronic Acid, Pistacia Lentiscus (Mastic) Gum, Acetyl Dipeptide-1 Cetyl Ester, Bee Venom, Crocus Chrysanthus Bulb Extract, Bis-PEG/PPG-20/5 PEG/PPG-20/5 Dimethicone, Methoxy PEG/PPG-25/4 Dimethicone, Cetearyl Alcohol, Caprylic/Capric Triglyceride, Glyceryl Polyacrylate, Sorbitan Laurate, Ethylhexylglycerin, Silica, PVP, PEG-8, Alcohol, Hydroxyethylcellulose, Cetrimonium Chloride, Chlorophenesin, Sodium Citrate, Tocopherol, Potassium Sorbate, PVM/MA Copolymer, Ascorbyl Palmitate, BHT, Ascorbic Acid, Citric Acid, Parfum, Phenoxyethanol, Pentaerythrityl Tetra-di-tbutyl Hydroxyhydrocinnamate, Disodium EDTA.