This course is an extension of the Melanogenesis & Pigmentation class, and focuses on the pathogenic mechanisms that cause PIH, and why there are limited treatment options of this condition. The objective of this course is to help us understand how it may be possible to prevent and improve this challenging skin condition.
This short specialty class is an extension of the base knowledge gained from the advanced skin analysis program or the simpler specialty class called melanogenesis. It has been written to help us understand how it may be possible to prevent and improve this challenging skin condition.
The presentation explores the pathogenic mechanism for keratinocyte-melanocyte degeneration in Post Inflammatory Hyper-pigmentation, and offers a fresh perspective to help understand the causes, of and limited treatment options of this condition.
- ■ Understand how keratinocytes can act as a source of the reactive oxygen species of radical by transferring hydrogen peroxide to melanocytes.
- ■ Review of oxidative stress and the increased reactive oxygen species generation including compromised antioxidant capacity of the cell and mitochondria membrane.
- ■ Examine the lipid component of cell membranes to further understand how lipid peroxidation compromises cellular functions and causes skin disorders such as post inflammatory hyperpigmentation.
- ■ Consideration of the genetic susceptibility for the photo type 4 to 6 phospholipid structure to oxidize